Mechanisms of pethidine-induced vasodilatation / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 166-169, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-341917
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the vasodilating effects of pethidine, particularly in association with intracellular calcium.</p><p><b>METHODS</b>Aorta rings of Sprague-Dawley rats, with or without endothelium, were prepared in organ bath to measure the vascular tone. Pre-contractions by KCl (80 mmol/L) and phenylephrine (PhE) (10(-6)mol/L) were induced.</p><p><b>RESULTS</b>Pethidine did not alter the resting tension of aorta rings, but produced dose-dependent relaxation in KCl and PhE pre-treated aorta rings with or without endothelium. Pethidine did not change the caffeine-stimulated contraction, and still had similar inhibition in KCl pre-contracted aorta rings after pretreatment with ruthenium red. Pethidine decreased the contractile responses induced by PhE in Ca(2+)-free solution or by adding calcium into Ca(2+)-free solution.</p><p><b>CONCLUSION</b>Pethidine could produce an endothelium-independent vasodilatation in KCl and PhE pre-contracted aorta rings, which is related to inhibition of Ca(2+)entry and IP3-sensitive Ca(2+) release in vascular smooth muscle.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Potassium Chloride
/
Vasodilator Agents
/
Caffeine
/
Calcium
/
Rats, Sprague-Dawley
/
Meperidine
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2004
Type:
Article
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