Expression of c-myc mRNA on early restenosis after carotid endarterectomy / 中华外科杂志
Chinese Journal of Surgery
;
(12): 555-557, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-342122
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression and changes of protooncogene c-myc in early restenosis after carotid endarterectomy (CEA).</p><p><b>METHODS</b>Using New Zealand Rabbits, carotid atherosclerotic stenosis (CASS) model were created. The expression of c-myc in early restenosis after CEA were detected by quantitative real-time polymerase chain reaction (qRT-PCR).</p><p><b>RESULTS</b>In this experiment protooncogene c-myc was analysed at pre-operation, 4 hours and 1 d after CEA by qRT-PCR, and the level of mRNA of c-myc was reached maximum at 4 hours, and decreased following significantly, but still higher than pre-operation.</p><p><b>CONCLUSIONS</b>The activation of protooncogene c-myc may be generator factor of vascular smooth muscle cell proliferation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Postoperative Complications
/
General Surgery
/
RNA, Messenger
/
Carotid Arteries
/
Carotid Artery Diseases
/
Random Allocation
/
Gene Expression
/
Proto-Oncogene Proteins c-myc
/
Endarterectomy, Carotid
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2007
Type:
Article
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