The relationship between the changes of proangiogenic factors serum concentrations and progression of pancreatic carcinoma patients / 中华外科杂志
Chinese Journal of Surgery
;
(12): 496-498, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-342136
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between VEGF, bFGF and IGF-1 serum concentration and progression of pancreatic carcinoma.</p><p><b>METHODS</b>Fifty-six patients with pancreatic carcinoma were divided into resectable group (n = 32) and unresectable group (n = 24). Another group was normal group (n = 20). The expression and significance of these proangiogenic factors were respectively analyzed in different groups.</p><p><b>RESULTS</b>For pancreatic carcinoma group, concentrations of VEGF and bFGF were significantly higher than these of normal group (P < 0.01). Serum VEGF was significantly correlated with the resection of pancreatic carcinoma (P < 0.05) while bFGF and IGF were not. According to univariate analysis, serum VEGF was correlated with tumor grade, nodal disease, vascular invasion, distant metastases and tumor stage. Serum bFGF was associated with tumor size and grade. Serum IGF-1 was correlated with vascular invasion.</p><p><b>CONCLUSIONS</b>Angiogenic factors play important roles in growth, invasion and metastasis. Detection of serum proangiogenic factors may have potential value in diagnosis and prognosis of pancreatic carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatic Neoplasms
/
Pathology
/
Prognosis
/
Blood
/
Insulin-Like Growth Factor I
/
Fibroblast Growth Factor 2
/
Disease Progression
/
Vascular Endothelial Growth Factor A
/
Metabolism
/
Neoplasm Invasiveness
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2007
Type:
Article
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