Study on the association of PPP1R3 gene polymorphism with type 2 diabetes in Han population of Anhui province / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 534-536, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-342317
ABSTRACT
<p><b>OBJECTIVE</b>To study the association of muscle-specific glycogen-targeting regulatory subunit of the glucogen-bound protein phosphatase 1 (PPP1R3) gene codon 905 Asp/Tyr polymorphism with type 2 diabetes in Chinese Han population in Hefei region of Anhui province.</p><p><b>METHODS</b>PPP1R3 gene Asp905Tyr polymorphism was detected by polymerase chain reaction and appropriate restriction enzyme (PCR-RFLP) in 262 type 2 diabetic cases and 104 normal controls. Case and control groups were divided into subgroups by body mass index (BMI) 25 kg/m2.</p><p><b>RESULTS</b>When PPP1R3 gene Asp905Tyr polymorphism was not associated with type 2 diabetes mellitus. When subjects with BMI < 25 kg/m2 and Tyr/Tyr genotypes were used as reference. Subjects with Asp905 and BMI > or = 25 kg/m2 had a 3.69-fold increase of risk suffering from type 2 diabetes (OR = 3.69, 95% CI 1.38-8.89, P=0.006).</p><p><b>CONCLUSIONS</b>PPP1R3 gene Asp905Tyr polymorphism did not seem to play a critical role in the development of type 2 diabetes mellitus in Han population of Chinese in Anhui province but interaction between the Asp905 and BMI cause the increase of risk of type 2 diabetes.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Tyrosine
/
Polymorphism, Restriction Fragment Length
/
China
/
Polymerase Chain Reaction
/
Epidemiology
/
Risk Factors
/
Aspartic Acid
/
Phosphoprotein Phosphatases
/
Diabetes Mellitus, Type 2
Type of study:
Etiology study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2004
Type:
Article
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