Progress in the structure and function of human carboxylesterase 1 / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1414-1422, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-342385
ABSTRACT
Human carboxylesterase 1 (HCE1), belonging to a multigene serine hydrolase family, is a major liver carboxylesterase responsible for the hydrolysis and metabolism of various xenobiotics. It also plays an important role in the transportation and metabolism of endogenous cholesterol ester and free fatty acid, and is closely associated with the pathogenesis of hepatocellular carcinoma. This review describes current developments in the molecular structure, the roles in drug, toxins and lipid metabolism, and the early diagnosis for hepatocellular carcinoma of human carboxylesterase 1.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Carboxylic Ester Hydrolases
/
Xenobiotics
/
Cholesterol Esters
/
Carcinoma, Hepatocellular
/
Diagnosis
/
Fatty Acids, Nonesterified
/
Genetics
/
Liver Neoplasms
/
Metabolism
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2012
Type:
Article
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