Preparation and degradation behavior of PELGE nanoparticles / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 921-925, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-342579
ABSTRACT
A series of poly (lacticacid-co-glycolicacid)-poly(ethylene glycol) (PLGA-PEG, PELGA) block copolymers and poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene-glycol) (PELGE) was synthesized by ring-opening polymerization. PELGA nanoparticles and PELGE nanoparticles were prepared using the emulsion-solvent evaporation technique (O/W). To study the behavior and mechanism of the degradation of PELGA-NP and PELGA-NP, we determined the lactic acids by UV spectrophotometry. The method confirmed that degradation was much faster for polymers with a decrease in the LA content of the polymers or an increase in the PEG content of the polymers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyesters
/
Polyethylene Glycols
/
Polyglactin 910
/
Polyglycolic Acid
/
Polymers
/
Biocompatible Materials
/
Biodegradation, Environmental
/
Drug Carriers
/
Chemistry
/
Drug Delivery Systems
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2004
Type:
Article
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