The influence of Bazhen decoction on hematopoietic modulator in anaemic mice / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 727-731, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-342625
ABSTRACT
This study was designed to evaluate the effect of Bazhen decoction on bone marrow depression induced by cyclophosphamide (CY) in mice. An experimental model of mouse bone marrow injury was established through cyclophosphamide induced and the following phenomena were observed. The techniques of culture of hematopoietic progenitor cell and hematopoietic growth factor assay were used. Bazhen decoction could obviously promote the proliferation of bone marrow cells of anaemic mice. The culture media of spleen cell, macrophage, lung and skeletal muscle treated with Bazhen decoction had much stronger stimulating effects on hematopoietic cells. The bone marrow cells of the anaemic mice could yield TNF through Bazhen decoction treatment. It was suggested that Bazhen decoction is clinically a hopeful drug used to cure bone marrow depression and attenuate the side effects of CY.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drugs, Chinese Herbal
/
Cyclophosphamide
/
Therapeutic Uses
/
Tumor Necrosis Factors
/
Drug Therapy
/
Hematopoiesis
/
Hematopoietic System
/
Anemia
/
Phytotherapy
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2004
Type:
Article
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