Regulatory genes of geldanamycin biosynthesis / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 717-722, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-342845
ABSTRACT
Two LAL family regulatory genes, gdmRI and gdmRII, were identified in the geldanamycin biosynthetic gene cluster of Streptomyces hygroscopicus 17997. Disruption of the two regulatory genes resulted in absolute elimination of geldanamycin biosynthesis. The complementation experiments using a single wild-type gene could restore geldanamycin production. These results indicated that both gdmRI and gdmRII were positive regulatory genes of the geldanamycin biosynthesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Repressor Proteins
/
Streptomyces
/
Protein-Tyrosine Kinases
/
Gene Expression Regulation, Bacterial
/
Trans-Activators
/
Benzoquinones
/
HSP90 Heat-Shock Proteins
/
Lactams, Macrocyclic
/
Genetics
/
Metabolism
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2008
Type:
Article
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