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p16 and MGMT gene methylation in sputum cells of uranium workers / 中华劳动卫生职业病杂志
Article in Chinese | WPRIM | ID: wpr-343054
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the methylation of O-6-methylguanine-DNA methyltransferase (MGMT) and p16 gene in the sputum cells of radon-exposed population. To provide the experimental base for finding the molecular biomarker of the high risk population of the radon-induced lung cancer.</p><p><b>METHODS</b>91 radon-exposed workers were divided into 4 groups, high dosage group (> 120 WLM), middle dosage group (between 60 and 120 WLM), low dosage group (between 30 and 60 WLB) and lower dosage group (between 2 and 30 WLM) according to the accumulated exposure dosage of the radon daughters. The abnormal methylation of p16 and MGMT gene in the sputum cells of the population in the four groups was detected with the methylation specific PCR (MSP).</p><p><b>RESULTS</b>There was significantly upward trend for the p16 gene methylation rate (0.00%-20.00%), the MGMT gene methylation rate (0.00%-28.00%) and the total methylation rate (0.00%-40.00%) with the increase of the accumulated exposure dosage of the radon daughters (P < 0.01).</p><p><b>CONCLUSION</b>The methylation of p16 and MGMT gene is related to the accumulate exposure dosage of the radon daughters.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Sputum / Humans / Male / Carcinogens, Environmental / Occupational Exposure / Radon / Radon Daughters / DNA Methylation / O(6)-Methylguanine-DNA Methyltransferase / Cyclin-Dependent Kinase Inhibitor p16 Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sputum / Humans / Male / Carcinogens, Environmental / Occupational Exposure / Radon / Radon Daughters / DNA Methylation / O(6)-Methylguanine-DNA Methyltransferase / Cyclin-Dependent Kinase Inhibitor p16 Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2006 Type: Article