Expression of pituitary tumor transforming gene and C-myc gene in patients with multiple myeloma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1238-1241, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-343311
ABSTRACT
The study was purposed to explore the expressions of pituitary tumor transforming gene and c-myc gene in patients with multiple myeloma (MM) and its relationship with pathogenesis of MM. Expressions of pituitary tumor transforming gene and c-myc gene mRNA in BMMNC from 33 patients with MM and 10 normal controls were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). The results showed that the expressions of pituitary tumor transforming gene and c-myc gene mRNA were significantly higher in MM patients those that in normal controls (p<0.05). The expression of pituitary tumor transforming gene mRNA was significantly correlated with the expression of c-myc gene (r=0.801, p<0.05). In conclusion, the overexpressions of pituitary tumor transforming gene and c-myc gene may be related to the pathogenesis and progression of MM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Case-Control Studies
/
Gene Expression Regulation, Neoplastic
/
Proto-Oncogene Proteins c-myc
/
Securin
/
Genetics
/
Metabolism
/
Multiple Myeloma
/
Neoplasm Proteins
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2009
Type:
Article
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