Synthesis of 4-, 6- or 7-substituted phenyliminomethylenecoumarins and their anticancer activities / 药学学报

ABSTRACT

<p><b>AIM</b>A series of substituted phenyliminomethylenecoumarins derivatives was designed in order to find compounds possessing anticancer activities.</p><p><b>METHODS</b>Title compounds (1a-b, 2a-b and 3a-q) were synthesized and screened by several anticancer models in vitro.</p><p><b>RESULTS</b>Twenty-one new compounds (1a-b, 2a-b and 3a-q) were synthesized and screened. Structures of the new compunds were determined by MS, HNMR and elemental analysis. Twelve compounds (3c, 3d, 3e, 3f, 3g, 3h, 3j, 3k, 3m, 3o, 3p, 3q) showed inhibitory effects on HCT-8, KB and Bel7402 cell lines in vitro.</p><p><b>CONCLUSION</b>Some compounds had certain anticancer activities and were worth further studying.</p>