Anti-gastric ulcer sesquiterpene lactone glycosides from Crepis napifera / 药学学报
Acta Pharmaceutica Sinica
;
(12): 33-36, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-343406
ABSTRACT
<p><b>AIM</b>The anti-gastric ulcer constituents from the roots of Crepis napifera (Franch) Babc (Compositae) were studied.</p><p><b>METHODS</b>Solvent partition, Si gel and Rp-18 column chromatography, crystallization and spectral methods were used to extract, isolate and identify two compounds. The activity of compound 1 was tested on the rat stomach by determining the effect on aspirin-induced gastric lesions and on histamine-stimulated gastric acid secretion.</p><p><b>RESULTS</b>Two sesquiterpene lactone glycosides, taraxinic acid-1'-O-beta-D-glucopyranoside (1) and 11,13-dihydro-taraxinic acid-1'-O-beta-D-glucopyranoside (2) were obtained. Compound 1 at the dose of 80 mg.kg-1 p.o. inhibited significantly the development of aspirin-induced gastric lesions in the rat and at an i.v. dose of 70 mg.kg-1 did not affect histamine-stimulated gastric acid secretion in the lumen-perfused rat stomach.</p><p><b>CONCLUSION</b>Compound 1 is the active component of the plant which protects gastric mucosa and exhibits anti-gastric ulcer action.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Sesquiterpenes
/
Stomach Ulcer
/
Molecular Structure
/
Chemistry
/
Aspirin
/
Rats, Wistar
/
Rats, Sprague-Dawley
/
Plant Roots
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2002
Type:
Article
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