Long-term results of postoperative electronic irradiation for 53 patients with keloids / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the results of postoperative radiotherapy with electronic beam for patients with keloids in our hospital.</p><p><b>METHODS</b>From September 2006 to May 2009, radiotherapy was given within 24 hours after operation in 53 keloid patients. With single vertical field irradiation, 6-12 Mev electronic beams of Linear Accelerator were selected for different incision depth in different sites. The field size was 1.0 cm (range 0.5-2.0 cm) away from both incision ends and 1.25 cm (range 0.75-2.50 cm) away from incision laterally. The radiation was given daily with median treatment course of 4 days (range 3-21 days) at 3.5 Gy/Fx to a median total dose of 14 Gy (range 8-20 Gy). SPSS 21. 0 was used for analysis.</p><p><b>RESULTS</b>All postoperative incisions healed in one stage, the median follow-up was 34 months (range 18-63 months). The overall local control rate was 79.7%. For patients who received the dose of more than 14 Gy versus less than 14 Gy, the local control rate was 81.6%, 75.2%, respectively (P > 0.05). For male and female, the 3 year local recurrence rate were 45.3%, 9.9% respectively (P = 0.008). Multivariate analysis showed that the sex (male versus female) was an independent prognostic factor (P = 0.036).</p><p><b>CONCLUSION</b>Surgery combined with electronic beam irradiation is a rather effective way to treat keloids. The local control rate would have a better trend if the total dose was higher than 14 Gy. Sex is an independent prognostic factor.</p>