An alternative model of composite tissue transplantation in rat: the femur osteomyocutaneous flap / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 29-32, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-343481
ABSTRACT
<p><b>OBJECTIVE</b>To reconstruct a simpler and reliable composite tissue transplantation model-the femur osteomyocutaneous flap for the replacement of hindlimb transplantation.</p><p><b>METHODS</b>Ten femur osteomyocutaneous flaps from 5 Lewis rats were transplanted into 10 syngeneic recipients' inguinal region. Their nutrient vessels were anastomosed with recipients vessels. The graft of this model was consisted of the groin flap and partial femur. To verify the feasibility of this model, gross and histological appearance were studied after transplantation to evaluate the viability of grafts.</p><p><b>RESULTS</b>The operative time was (159.0 +/- 8.3) min with the harvesting time of (68.0 +/- 4.8) min and the ischemia time of (55. 8 +/- 6.8) min. The methylene blue injection showed rich blood supply of transplanted femur osteomyocutaneous flap. All the 10 flaps survived completely with pink skin color and hair regrowth. The histologic examination of the flaps also revealed the normal appearance of the viable skin and bone marrow.</p><p><b>CONCLUSIONS</b>The femur osteomyocutaneous flap is a simple and reliable model for composite tissue transplantation, and its establishment will provide a new tool for the study of composite tissue allografts.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rats, Inbred Lew
/
Surgical Flaps
/
Transplantation
/
Tissue Transplantation
/
Bone Transplantation
/
Skin Transplantation
/
Muscle, Skeletal
/
Models, Animal
/
Femur
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2014
Type:
Article
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