Castration affects the expression of androgen receptor and epidermal growth factor in rat submaxillary salivary gland / 中华男科学杂志
National Journal of Andrology
;
(12): 540-544, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-343577
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of castration on the quantity of androgen receptor (AR) and the epidermal growth factor (EGF) in the submaxillary salivary glands of castrated rats.</p><p><b>METHODS</b>Sixty male Wistar rats, aged 30 to approximately 60 days, were randomly divided into three groups of 20 rats castrated, sham-operated and normal control (unoperated). The submaxillary salivary glands of the castrated rats were removed one week after surgery, and so were those of the rats in the sham-operated and the normal control groups. The homogenized salivary gland was used for Western-blots.</p><p><b>RESULTS</b>The quantity of AR and EGF in the submaxillary salivary glands was decreased significantly in the castrated rats compared with that in the sham-operated and the normal control ( P < 0. 05). Moreover, EGF secreted by the submaxillary salivary glands was also decreased in the castrated rats (P < 0.05).</p><p><b>CONCLUSION</b>Castration affected the production of androgen receptor in the salivary gland, and also, could further affect the secretion of EGF from the salivary gland.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Submandibular Gland
/
Orchiectomy
/
Random Allocation
/
Receptors, Androgen
/
Blotting, Western
/
Rats, Wistar
/
Epidermal Growth Factor
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2006
Type:
Article
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