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Nuclear localization region in soluble adenylyl cyclase / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 280-284, 2005.
Article in Chinese | WPRIM | ID: wpr-343722
ABSTRACT
<p><b>OBJECTIVE</b>To locate the region responsible for nuclear localization of protein sAC.</p><p><b>METHODS</b>The eukaryotic expression vector of vairous sAC deletion mutants were transfected into Hela cells. The localization of each mutant was observed using confocal microscope.</p><p><b>RESULTS</b>For some mutants, the localization of sAC changed. Deletion of some region made it unable to locate in the nuclear.</p><p><b>CONCLUSION</b>It is possible to figure out that the nucleotide region (739-1038 and 1045-1261) take charge of nuclear localization of sAC.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Nuclear Proteins / Adenylyl Cyclases / Genetic Testing / Microscopy, Confocal / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Diabetes Mellitus, Type 2 / Genetics Limits: Female / Humans / Male Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Nuclear Proteins / Adenylyl Cyclases / Genetic Testing / Microscopy, Confocal / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Diabetes Mellitus, Type 2 / Genetics Limits: Female / Humans / Male Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2005 Type: Article