Nuclear localization region in soluble adenylyl cyclase / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 280-284, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-343722
ABSTRACT
<p><b>OBJECTIVE</b>To locate the region responsible for nuclear localization of protein sAC.</p><p><b>METHODS</b>The eukaryotic expression vector of vairous sAC deletion mutants were transfected into Hela cells. The localization of each mutant was observed using confocal microscope.</p><p><b>RESULTS</b>For some mutants, the localization of sAC changed. Deletion of some region made it unable to locate in the nuclear.</p><p><b>CONCLUSION</b>It is possible to figure out that the nucleotide region (739-1038 and 1045-1261) take charge of nuclear localization of sAC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Nuclear Proteins
/
Adenylyl Cyclases
/
Genetic Testing
/
Microscopy, Confocal
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Diabetes Mellitus, Type 2
/
Genetics
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2005
Type:
Article
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