Role of procalcitonin in the differentiation and surveillance of systemic inflammatory response syndrome / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 48-52, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-343768
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the discrimination of serum procalcitonin (PCT) and interleukin-6 (IL-6) between patients with sepsis and non-infectious inflammatory response syndrome (SIRS) and the prediction power of clinical outcome.</p><p><b>METHODS</b>A perspective study was performed in 27 patients with sepsis and 30 patients with non-infectious SIRS. The serum concentrations of PCT, IL-6, C-reactive protein (CRP), white blood cell count, percentage of neutrophil, absolute neutrophil count, and maximal body temperature were obtained less than 24 hours after clinical onset of sepsis or SIRS.</p><p><b>RESULTS</b>The serum levels of PCT and IL-6 and percentage of neutrophil were significantly higher in patients with sepsis than in those with non-infectious SIRS (PCT 5.54 [1.20, 32.74] microg/L vs 0.77 [0.22, 3.90] microg/L, P=0.001; IL-6 163.66 [33.60, 505.26] ng/L vs 37.72 [22.52, 110.78] ng/L, P=0.004; CRP [15.28 +/- 8.41] g/L vs [9.51 +/- 7.65] g/L, P=0.010; and percentage of neutrophil 0.91 +/- 0.04 vs 0.88 +/- 0.04, P=0.010). Receiver operating characteristic curve showed that the power of PCT and IL-6 were the best of all above. There was significant correlation between serum PCT or IL-6 and the acute physiology and chronic health evaluation (APACHE II) or sepsis-related organ failure assessment (SOFA) scores, so was between serum PCT and the intensive care unit (ICU) length of stay.</p><p><b>CONCLUSIONS</b>PCT and IL-6 are more reliable indicators to differentiate sepsis and non-infectious SIRS than the conventional inflammatory markers, and correlate with the disease severity. PCT levels are significantly correlated with ICU length of stay.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Precursors
/
Blood
/
C-Reactive Protein
/
Calcitonin
/
Calcitonin Gene-Related Peptide
/
Prospective Studies
/
Interleukin-6
/
Systemic Inflammatory Response Syndrome
/
Sepsis
/
APACHE
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Screening study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2005
Type:
Article
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