Effect of xiaoyin recipe in treatment of psoriasis patients of blood-heat syndrome type and its impact on peripheral Th1/Th2 equilibrium / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 683-685, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-343918
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of Chinese medicinal therapy for cooling blood and removing stasis (CBRS) in treating psoriasis of blood-heat syndrome type by observing its clinical efficacy and impact on serum level of cytokines.</p><p><b>METHODS</b>Changes of psoriasis area and severity index (PASI) scores, scores of syndrome and serum levels of tumor necrosis factor alpha (TNF-alpha, Th1 cytokine) and interleukin-10 (IL-10, Th2 cytokine) in 32 psoriatic patients before and after treatment were observed.</p><p><b>RESULTS</b>The total effective rate after 4 weeks of treatment and 8 weeks of treatment was 65.63% (21/32 cases) and 75.00% (24/32 cases) respectively. Scores of PASI and syndrome all improved after treatment (P < 0.05). And comparison of TNF-alpha level before and after treatment also showed significant difference (P < 0.05) , whereas that of IL-10 was insignificant (P > 0.05). Moreover, a positive correlation was found between PASI scores and secreting level of TNF-alpha in patients with psoriasis (r = 0.3709, P < 0.05).</p><p><b>CONCLUSION</b>Chinese therapy for CBRS could play its effect in treating psoriasis by way of reducing TNF-alpha level.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Psoriasis
/
Blood
/
Drugs, Chinese Herbal
/
Case-Control Studies
/
Cytokines
/
Th2 Cells
/
Th1 Cells
/
Therapeutic Uses
/
Drug Therapy
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2008
Type:
Article
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