Effect of Chinese herbal medicine in the natural cycle of frozen embryo transfer / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of Chinese herbal medicine on the clinical pregnancy rate and implantation rate of frozen embryo transfer (FET) in a natural cycle.</p><p><b>METHODS</b>Women with frozen embryos planned to receive FET and had spontaneous ovulation in a natural cycle were chosen for observation. They were assigned to the treated group and the control group, both were treated with conventional medicine in the very month of FET, but to the treated group, Chinese herbal medicine was given additionally. The clinical pregnant rate, implantation rate, endometrial thickness during transferring, as well as the levels of estrogen and progesterone 2 weeks after transfer in the two groups were observed and compared.</p><p><b>RESULTS</b>The clinical pregnancy rate and implantation rate in the treated group were significant higher than those in the control group, 47.37% (36/76 cases) vs 32.14% (54/168 cases) and 22.38% (47/210 embryos) vs 16.09% (74/460 embryos), respectively (all P <0.05). Difference between the two groups in endometrial thickness, levels of estrogen and progesterone showed no statistical significance (P > 0.05).</p><p><b>CONCLUSION</b>Chinese herbal medicine could enhance the clinical pregnancy rate and implantation rate in the natural cycle of FET to certain extent.</p>