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Treatment of acute radiation pneumonia with Qingfei Huatan Quyu method / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 414-417, 2008.
Article in Chinese | WPRIM | ID: wpr-343964
ABSTRACT
<p><b>OBJECTIVE</b>To observe the therapeutic effect of Qingfei Huatan Quyu method (QHQ, a Chinese medicinal therapy for clearing Fei-heat and dissolving phlegm-stasis) combined with hormone-antibiotic therapy (HAT) on radiation pneumonia (RP).</p><p><b>METHODS</b>Eighty-one patients with RP were randomized into two groups, 41 patients in the control group and 40 in the treatment group were treated with HAT alone and HAT combined with QHQ respectively for 21 days. The severity of RP was evaluated before and after treatment according to the criteria of the radiation therapy oncology group. The effect on TCM symptoms and chest roentgenogram, as well as on plasma levels of interleukin-6 ( IL-6) and transform growth factor-beta (TGF-beta) were detected.</p><p><b>RESULTS</b>After treatment, number of patients with RP graded as 0, 1, 2, 3, and 4 in the treatment group was 23, 10, 4, 2, and 1, respectively, while in the control group, 14, 9, 11, 4, and 3, respectively. The combined therapy showed effects in improving RP grading (P <0.01) and TCM syndromes were superior to those of HAT respectively (P < 0.05). Besides, levels of IL-6 and TGF-beta were lowered after treatment in the treatment group, showing a significant difference to those in the control group (P <0.05).</p><p><b>CONCLUSION</b>QHQ combined with HAT has a definite therapeutic effect on RP. It could efficiently decrease the plasma levels of IL-6 and TGF-beta in patients with RP.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Drugs, Chinese Herbal / Transforming Growth Factor beta / Interleukin-6 / Radiation Pneumonitis / Therapeutic Uses / Drug Therapy / Drug Therapy, Combination / Medicine, Chinese Traditional / Anti-Bacterial Agents Type of study: Controlled clinical trial / Diagnostic study Limits: Humans Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Drugs, Chinese Herbal / Transforming Growth Factor beta / Interleukin-6 / Radiation Pneumonitis / Therapeutic Uses / Drug Therapy / Drug Therapy, Combination / Medicine, Chinese Traditional / Anti-Bacterial Agents Type of study: Controlled clinical trial / Diagnostic study Limits: Humans Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2008 Type: Article