The role of vitagene in aging and Alzheimer's disease and relevant advances of pharmacological study / 药学学报
Acta Pharmaceutica Sinica
;
(12): 825-832, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-344034
ABSTRACT
Free radical hypothesis of aging emphasized that the age-related accumulation of free radicals results in cell injury. Alzheimer's disease (AD) is the most common form of neurodegenerative disease characterized by impaired cognition and memory of the elderly. Aging is a key risk factor in AD. Substantial evidence suggests that imbalance between free radical formation and clearance promotes AD pathogenesis. The brain overcomes oxidative stress by inducing expression of a set of genes called vitagenes. The protein products of vitagenes include heat shock proteins, heme oxygenases and thioredoxin systems, which serve as endogenous lifeguard of cells. This paper is a review of the expression and function of vitagenes in aging and AD brain, as well as relevant pharmacological study.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thioredoxins
/
Brain
/
Aging
/
Oxidative Stress
/
Alzheimer Disease
/
Genetics
/
Heat-Shock Proteins
/
Heme Oxygenase (Decyclizing)
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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