Advances in the study of affinity selection-ultrafiltration/HPLC-MS / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1084-1088, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-344053
ABSTRACT
Affinity selection-ultrafiltration/HPLC-MS is the combination of the ultrafiltration and HPLC-MS, mainly used for screening small active molecular substances from combinatorial libraries and natural product extracts, which can bind to solution-phase targets. Besides, it can be used in metabolic screening and characterization of ligand-receptor binding. It is a complement to the traditional methods of screening and identifying drugs. This review describes its principle and application in drug study.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
Mass Spectrometry
/
Pharmaceutical Preparations
/
Ultrafiltration
/
Chromatography, High Pressure Liquid
/
Combinatorial Chemistry Techniques
/
Drug Evaluation, Preclinical
/
Small Molecule Libraries
/
Ligands
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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