Bradykinin modulates ion channel in inflammatory pain / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1066-1071, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-344055
ABSTRACT
Injury or inflammation induces release of a range of inflammatory mediators. Bradykinin is one of the most important inflammatory mediators and plays a crucial role in mediating inflammatory pain. It is well known that multiple ion channels located in the nociceptors participate in pain sensation. Recent studies demonstrate an important role of bradykinin in regulating the function and expression of pain-related ion channels. This paper summarizes the recent advances in the understanding of the role of bradykinin in modulation of the channels and discusses future possibilities in the treatment of inflammatory pain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain
/
Pharmacology
/
Physiology
/
Bradykinin
/
Sodium Channels
/
Receptors, N-Methyl-D-Aspartate
/
Receptors, AMPA
/
Inflammation Mediators
/
KCNQ Potassium Channels
/
Transient Receptor Potential Channels
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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