Progress on targeting TRAIL's receptor as antitumor strategy / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1336-1342, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-344075
ABSTRACT
There exist two major apoptotic signaling pathways the intrinsic mitochondria-mediated pathway, and the extrinsic death receptor-induced pathway. TNF-related apoptosis-inducing ligand (TRAIL), which is the ligand for death receptor 4 (DR4) and death receptor 5 (DR5) and induces apoptosis by ligation with DR4 or DR5. We review the characteristic of TRAIL and its receptors, the mechanism of apoptosis induced by TRAIL, the distribution of death receptors in cancer, and applications and prospects of TRAIL signaling pathway in the treatment of cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Therapeutics
/
Genetic Therapy
/
Signal Transduction
/
Classification
/
Drug Delivery Systems
/
Apoptosis
/
Therapeutic Uses
/
TNF-Related Apoptosis-Inducing Ligand
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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