Advances in study of metabolic activation of carboxyl-acid containing drugs by UGTs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1193-1199, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-344094
ABSTRACT
The metabolic transformation of the drugs containing carboxylic acid groups can lead to the formation of acyl glucuronide metabolites through catalysis by glucuronosyltransferase, and produce pro-acyl glucuronide intermediate metabolites with electronic activity. Then, protein or DNA adducts appeared after a series of non-enzyme or enzyme reactions. These adducts would change the protein activity and potentially lead to idiosyncratic and genotoxicity. In this paper, we discussed the chemical activity, drug-induced mechanisms, distribution and toxicity resulting from this metabolic activation for these drugs, and stated the status and prospects of research in this field.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biological Transport, Active
/
DNA Damage
/
Carboxylic Acids
/
Pharmaceutical Preparations
/
Biotransformation
/
Glucuronosyltransferase
/
Glucuronides
/
Hepatocytes
/
Drug-Related Side Effects and Adverse Reactions
/
Toxicity
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS