C1772T polymorphism of hypoxia-inducible factor-1 alpha gene in Han ethnic population from Northern China / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 267-270, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-344338
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the distribution of single nucleotide polymorphism C1772T (SNP/C1772T) in hypoxia-inducible factor -1 alpha (HIF-1 alpha) gene in Han ethnic population from Northern China.</p><p><b>METHODS</b>Allele frequencies in a sample of 206 healthy Chinese Hans were determined by polymerase chain reaction followed by restriction fragment length polymorphism.</p><p><b>RESULT</b>The genotype frequencies of C1772T observed in Chinese Hans were 93 % and 7% for CC and CT respectively; and allele frequencies were 96% and 4 %for C and T respectively. There was significant difference in distribution of allele frequencies between Chinese Hans and Caucasian.</p><p><b>CONCLUSION</b>The single nucleotide polymorphism of C1772T in HIF-1 alpha gene has difference in different ethnic population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
China
/
Polymorphism, Single Nucleotide
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Ethnology
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Adolescent
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS