Relationship between measurements of tidal volume and thoracic inflating volume by pressure plethysmography in mice / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 257-260, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-344340
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the accordance of tidal volume (TV) with thoracic inflating volume (TIV) measured by pressure whole-body or double-chamber plethysmography in mice.</p><p><b>METHODS</b>TV and TIV by double-chamber plethysmography were simultaneously measured in 6 mice with spontaneous respiratory frequencies 90 - 120/min; TV and TIV by whole-body plethysmography were measured in 8 paralyzed mice ventilated by fixed frequency.</p><p><b>RESULT</b>TIV value by double-chamber plethysmography was significantly higher than TV [(0.369 +/- 0.014) ml vs (0.356 +/- 0.012) ml, P < 0.01)] in 6 spontaneously breathing mice. TIV value by whole-body plethysmography was significantly lower than TV[(0.233 +/- 0.003) ml vs 0.3 ml, P < 0.001] in 8 paralyzed mice.</p><p><b>CONCLUSION</b>The TV value assessed by TIV measurement can not be accurate, because of the humidifying and heating of inhaled air and negative thoracic pressure during the measurement.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plethysmography, Whole Body
/
Respiratory Function Tests
/
Thorax
/
Tidal Volume
/
Mice, Inbred BALB C
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2008
Type:
Article
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