Determination of dimethyl sulphate residual in granisetron hydrochloride by headspace gas chromatography / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 156-158, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-344359
ABSTRACT
<p><b>OBJECTIVE</b>To develop a headspace gas chromatography method for determining dimethyl sulphate residual in granisetron hydrochloride.</p><p><b>METHODS</b>An Angilent INNOWAX capillary column with nitrogen gas as carrier and FID as detector was applied in this study. Dimethyl sulphate was tested under a constant column temperature.</p><p><b>RESULT</b>Dimethyl sulphate had different retention time from other organic solvents such as alcohol,acetoacetate, isopropanol, dichlormethane and chloroform, which might exist in granisetron hydrochloride. The detection limit of dimethyl sulphate;s was 0.0016%.</p><p><b>CONCLUSION</b>The method can be used for the determination of dimethyl sulphate residual in granisetron hydrochloride.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sulfuric Acid Esters
/
Pharmaceutical Preparations
/
Drug Contamination
/
Chromatography, Gas
/
Granisetron
/
Methods
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2008
Type:
Article
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