Different gene expression during hepatocarcinogenesis in tree shrew induced by aflatoxin B1 / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 96-98, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-344503
ABSTRACT
<p><b>OBJECTIVE</b>To understand the molecular mechanism and find out the responsible genes for liver cancer by exploring the regulation of gene expression during hepatocarcinogenesis in tree shrew induced by aflatoxin B1 (AFB1).</p><p><b>METHODS</b>The tissues from tree shrew of different stages during the pathogenesis and development of hepatocellular carcinoma (HCC), liver cancer tissue, para-cancerous tissues, pre-cancerous liver tissues, liver tissues of the same stage from normal controls and the liver tissues taken before AFB1-treatment were analyzed for gene expression by cDNA array.</p><p><b>RESULTS</b>Four patterns of gene expression were observed during AFB1-induced hepatocarcinogenesis. They were genes up-regulated in HCC tissue and para-cancerous tissue, especially in HCC tissues; genes with similar expressing level in both HCC tissue and para-cancerous tissue, but higher than that in pre-cancerous tissue; genes down-regulated in HCC tissue; genes up-regulated before HCC appeared but down-regulated after HCC appeared.</p><p><b>CONCLUSION</b>Dynamic observation of gene expression will be beneficial to elucidate the mechanisms of AFB1- induced hepatocarcinogenesis and locate the responsible genes.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tupaiidae
/
Aflatoxin B1
/
Oligonucleotide Array Sequence Analysis
/
Gene Expression Profiling
/
Toxicity
/
Genetics
/
Liver Neoplasms, Experimental
/
Methods
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2003
Type:
Article
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