Protection on myocardial ischemia and reperfusion injury by Salvia miltiorrhiza hairy root in isolated Langendorff rat hearts / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>Protection by Salvia miltiorrhiza hairy root on myocardial ischemia and reperfusion injury in isolated Langendorff rat hearts was observed.</p><p><b>METHOD</b>Isolated rat hearts were perfused with 14, 28, 56 mg x L(-1) for 10 min followed by a 10 min washout period before the induction of 30 min normothermic global ischemia and 60 min of reperfusion.</p><p><b>RESULT</b>Our results showed that S. miltiorrhiza hairy root reduced the incidence of reperfusion-induced VF and VT and delayed the onset time of VF and VT. The increased aortic flow and content of SOD with decreased release of LDH and MDA were found.</p><p><b>CONCLUSION</b>Our results show that S. miltiorrhiza hairy root can prevent postischmic abnormalities in reperfusion arrhythmias, aortic flow and myocardium metabolism, which was similar to actions of S. miltiorrhiza.</p>