Effect of several penetration enhancers on transdermal absorption in vitro of syringin, chologenic acid and rutin in Xuelian cataplasm / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1661-1664, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-344562
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of different penetration enhancers on the transcutaneous permeability of syringin, chologenic acid and rutin in Xuelian cataplasm in vitro and to determine the effective enhancer.</p><p><b>METHOD</b>Using improved Franz-type diffusion cell and excised big mouse skin in vitro as transdermal barrier, the kinetics parameters of syringin, chologenic acid and rutin in Xuelian cataplasm such as cumulative permeation quantity, permeation rate were determined by HPLC. The enhancement ability of azone (A-zone), propylene glycol (PG) was investigated when used either uniquely or combinatively.</p><p><b>RESULT</b>With the 7% azone, the syringin, chologenic acid and rutin in Xuelian cataplasm could penetrate through the skin of rats well.</p><p><b>CONCLUSION</b>The selection of the best penetration enhancers provide reference for Xuelian cataplasm.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Phenylpropionates
/
Rutin
/
Skin Absorption
/
In Vitro Techniques
/
Drug Carriers
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Chemistry
/
Propylene Glycol
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS