Antidepressant-like effects of piperine and its neuroprotective mechanism / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1562-1565, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-344580
ABSTRACT
<p><b>OBJECTIVE</b>To observe the antidepressant effect of piperine and its neuroprotective mechanism.</p><p><b>METHOD</b>The behavioral studies were performed in forced swimming test (FST) and tail suspension test (TST). To further explore the mechanisms underlying their antidepressant-like activities, CORT-induced neuroblastoma SH-SY5Y cells and isolated and cultured neural progenitor cells. By using MTT assay, the effect of piperine on neural cells proliferation was observed.</p><p><b>RESULT</b>The research results indicated that after a week of administration, piperine (10, 20 mg x kg(-1)) could significantly reduce the duration of immobility in both FST and TST. Piperine has the protective effect on neuroblastoma cells and increased proliferation of hippocampus neural progenitor cells.</p><p><b>CONCLUSION</b>In the present study, we demonstrated that the antidepressant-like effects of piperine and its mechanisms might be involved by up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperidines
/
Stem Cells
/
Random Allocation
/
Cell Line
/
Cells, Cultured
/
Neuroprotective Agents
/
Cell Biology
/
Cell Proliferation
/
Alkaloids
/
Benzodioxoles
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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