Anti-thrombosis effect and its mechanism of Qingkailing injection / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1549-1552, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-344583
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the anti-thrombosis effect and its mechanism of Qingkailing injection (QKL).</p><p><b>METHOD</b>SD rats were randomly divided into control group, model group and QKL 2.5, 5.0, 10 groups. QKL were given (i.p.) to rats once a day for successively 4 days. The rats in all groups but control were pretreated with carrageenin (Ca) i.p. at 16 h before the last dose of QKL and followed by intravenous injection of endotoxin ( LPS fom E. coli O111B4) 50 microg x kg(-1) 30 min after the last dosing of QKL. Thrombosis in rat tails were observed at 24 h after injection of LPS. The number of white blood cells and platelets, serum TNF-alpha, IL-6 level, CD11b/CD18 expression of white blood cells and platelet aggregation were analysed.</p><p><b>RESULT</b>QKL obviously inhibited the LPS/Ca-induced thrombosis as showed a reduced infarction range due to thrombosis in tails. The sera concentration of TNF-alpha and IL-6, expression of CD11b/CD18 in WBC and platelet coagulation rate were reduced after QKL treatment.</p><p><b>CONCLUSION</b>The anti-thrombosis action of QKL is associated with inhibition of WBC activation and adherence, reduction of inflammatory factor release and abating of platelet coagulation rate. The anti-thrombosis mechanism of QKL is consistent with its function of clearing away heat-evil and toxic materials.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thrombosis
/
Blood
/
Drugs, Chinese Herbal
/
Random Allocation
/
Gene Expression
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Rats, Sprague-Dawley
/
CD18 Antigens
/
CD11 Antigens
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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