Effects of mechanical stimulation on expression of integrin subunits in chondrocyte / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 266-268, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-344630
ABSTRACT
Osteoarthritis (OA) is a kind of degenerative disease characterized by hyperosteogeny at the joint margins and articular cartilage degeneration. Mechanical stress can regulate the multiple functions of cells. The integrin as one of the mechanoreceptors on the surface of cells, mainly mediated adhesion between cells and extracellular matrix, which plays an important role in the mechanical signal transmission to regulate the physiological functions of cell. Therefore, it is very important to select proper mechanical stimulation (such as naprapathy) in the early and middle stage of osteoarthritis, which regulate the expression of integrins to affect the function of chondrocytes, repair the damaged chondrocyte and delay the articular cartilage degeneration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Biomechanical Phenomena
/
Integrins
/
Gene Expression Regulation
/
Chondrocytes
/
Protein Subunits
/
Cell Biology
/
Mechanical Phenomena
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2011
Type:
Article
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