Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice
Nutrition Research and Practice
;
: 472-479, 2015.
Article
in English
| WPRIM
| ID: wpr-34493
ABSTRACT
BACKGROUND/OBJECTIVES:
The goal of this study was to examine the effect of Sargassum coreanum extract (SCE) on blood glucose concentration and insulin resistance in C57BL-KsJ-db/db mice. MATERIALS/METHODS:
For 6 weeks, male C57BL/KsJ-db/db mice were administrated SCE (0.5%, w/w), and rosiglitazone (0.005%, w/w).RESULTS:
A supplement of the SCE for 6 weeks induced a significant reduction in blood glucose and glycosylated hemoglobin concentrations, and it improved hyperinsulinemia compared to the diabetic control db/db mice. The glucokinase activity in the hepatic glucose metabolism increased in the SCE-supplemented db/db mice, while phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activities in the SCE-supplemented db/db mice were significantly lower than those in the diabetic control db/db mice. The homeostatic index of insulin resistance was lower in the SCE-supplemented db/db mice than in the diabetic control db/db mice.CONCLUSIONS:
These results suggest that a supplement of the SCE lowers the blood glucose concentration by altering the hepatic glucose metabolic enzyme activities and improves insulin resistance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphoenolpyruvate
/
Blood Glucose
/
Glycated Hemoglobin
/
Insulin Resistance
/
Glucose-6-Phosphatase
/
Sargassum
/
Glucokinase
/
Glucose
/
Hyperglycemia
/
Hyperinsulinism
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Nutrition Research and Practice
Year:
2015
Type:
Article
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