The effect of Xuefu Zhuyu Decoction on in vitro endothelial progenitor cell tube formation / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 50-53, 2010.
Article
in English
| WPRIM
| ID: wpr-344949
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Xuefu Zhuyu Decoction ()-containing serum (XFZYD-CS) on endothelial progenitor cell (EPC) tube formation in vitro.</p><p><b>METHODS</b>Mononuclear cells from rat bone marrow were prepared in a Ficoll density gradient centrifuge. EPCs were separated by the differential attachment method, and observed with inverted microscope for the effect of XFZYD-CS on EPC tube formation.</p><p><b>RESULTS</b>After one day, EPCs exposed to the serum containing 5%, 10% and 15% XFZYD-CS formed typical tubes or vessel networks. The tube formation time was two days ahead of the control group and the size of most tubes in the serum groups was smaller than in the control group.</p><p><b>CONCLUSION</b>XFZYD-CS could induce EPC angiogenesis and hasten tube formation, especially in capillary vessels. The study provides experimental evidence for the plausibility of Xuefu Zhuyu Decoction in the treatment of ischemic diseases.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Stem Cells
/
Drugs, Chinese Herbal
/
Cell Differentiation
/
Cells, Cultured
/
Rats, Sprague-Dawley
/
Neovascularization, Physiologic
/
Cell Biology
/
Endothelial Cells
Limits:
Animals
Language:
English
Journal:
Chinese journal of integrative medicine
Year:
2010
Type:
Article
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