Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 341-346, 2009.
Article
in English
| WPRIM
| ID: wpr-344983
ABSTRACT
<p><b>OBJECTIVE</b>To determine the bioinformatical characteristics of differential gene expression in patients with chronic superficial gastritis (CSG) with the Pi-deficiency syndrome (PDS) and those of the non-Pi-deficiency syndrome (non-PDS), i.e. patients of CSG with Pi-Wei dampnese-heat syndrome and healthy persons.</p><p><b>METHODS</b>With the BRB-Array Tools software package, original data collection and bioinformatic analysis of gene arrays were conducted in 6 CSG patients of PDS (CSG-PDS), 6 CSG patients of non-PDS (CSG-nPDS), and 6 healthy volunteers (Normal).</p><p><b>RESULTS</b>Compared with non-PDS, the gene expressions in PDS with regards to protein synthesis, energy metabolism, immune reaction and ionic transport tended to be down-regulated, while those concerning secretion, cytoskeleton and ubiquitinization were up-regulated dominantly.</p><p><b>CONCLUSIONS</b>The two kinds of samples, CSG-PDS/Normal and CSG-PDS/CSG-nPDS, have their respective gene expression profiles with different characteristics. Gene expression profile has certain referential significance in syndrome classification.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Syndrome
/
Cluster Analysis
/
Chronic Disease
/
Computational Biology
/
Oligonucleotide Array Sequence Analysis
/
Gastritis
/
Genetics
Limits:
Humans
Language:
English
Journal:
Chinese journal of integrative medicine
Year:
2009
Type:
Article
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