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Peripheral plasma Big endothelin 1 levels in patients with gastric carcinoma undergoing radical gastrectomy and its relationship with tumor recurrence / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 34-37, 2006.
Article in Chinese | WPRIM | ID: wpr-345133
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the plasma Big endothelin-1 levels in patients with gastric carcinoma before and after radical gastrectomy, and explore its clinical significance.</p><p><b>METHODS</b>One hundred and six patients with gastric carcinoma and 20 controls were enrolled. The Big ET-1 plasma levels were examined by enzyme-linked immuno absorbent assay before and on the 1st, 3rd, and 10th day after curative surgery, and then were tested every 3 months in the patients with advanced gastric cancer.</p><p><b>RESULTS</b>All patients, except those with stage I gastric cancer, had significantly higher mean plasma Big ET-1 levels compared with normal controls (P=0.000). Higher plasma Big ET-1 levels were associated with lymph node metastasis (P=0.020) and serosal infiltration (P=0.035). The plasma Big Endothelin-1 levels were markedly increased on the first post-operative day (1st POD) in all patients,but decreased on the 3rd POD with no significant difference compared to the preoperative levels. On the 10th POD, the patients with stage I and II gastric cancer showed marked reduction in plasma Big ET-1 levels (P=0.010 and P=0.000, respectively), whereas no significant difference was observed in stage III and IV patients. During the follow-up, the plasma Big ET-1 levels just before recurrence in stage II patients were significantly higher compared with the levels on the 10th POD (P=0.011).</p><p><b>CONCLUSIONS</b>Plasma Big ET-1 might be a reliable marker to determine the severity of gastric carcinoma. Monitoring plasma Big ET-1 levels after curative resection in stage II gastric cancer patients is valuable to predict recurrence.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Stomach Neoplasms / General Surgery / Blood / Case-Control Studies / Follow-Up Studies / Endothelin-1 / Gastrectomy / Neoplasm Recurrence, Local / Neoplasm Staging Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Stomach Neoplasms / General Surgery / Blood / Case-Control Studies / Follow-Up Studies / Endothelin-1 / Gastrectomy / Neoplasm Recurrence, Local / Neoplasm Staging Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2006 Type: Article