Expressions of RhoC, CD44v6 and ICAM-1 in human gastric cancer and its clinicopathological significance / 中华胃肠外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expressions of RhoC, CD44v6 and ICAM-1 in gastric cancer and their correlations.</p><p><b>METHODS</b>SABC immunohistochemistry was used to detect the expressions of RhoC, CD44v6 and ICAM-1 in the specimens from 40 cases with gastric cancer. Their correlations were reviewed by clinicopathological data.</p><p><b>RESULTS</b>The expression of RhoC, CD44v6 and ICAM-1 were not correlated with tumor differentiation and invasion depth (P> 0.05), but significantly correlated with lymph metastasis and pTNM stage (P< 0.05). There was a significant correlation between the expression of RhoC and the expression of CD44v6 or ICAM-1 (r=0.355, P=0.006; r=0.354, P=0.003) respectively. If RhoC was positive-expressed, and either of CD44v6 or ICAM-1 was positive-expressed, the sensitivity and the specificity for predicting the lymphatic metastasis was 93.75%, 62.5% respectively.</p><p><b>CONCLUSIONS</b>The positive expressions of RhoC, CD44v6 and ICAM-1 are useful biological markers for predicting the metastatic potential of gastric cancer. The combined detection of three markers is a useful method for predicting lymphatic metastasis of gastric cancer.</p>