Expression of gastrin and gastrin releasing peptide in patient's with gastric cancer by using tissue chip technique / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 159-161, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-345213
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of gastrin(GAS) and gastrin releasing peptide(GRP) in patients with gastric cancer and investigate the clinical significance.</p><p><b>METHODS</b>The expression of GAS and GRP in sixty patients with gastric cancer was detected by using tissue chip technique and immunohistochemical methods.</p><p><b>RESULTS</b>The positive rates of GAS and GRP were 30.0% and 11.7% respectively in 60 cases with gastric cancer. The positive rates of GAS and GRP were higher in moderately and poorly differentiated cancers than those in well differentiated cancer (P< 0.05). The positive rates of GAS and GRP were significantly higher in mucinous adenocarcinoma and signet-ring cell carcinoma than those in other types of gastric cancer (P< 0.05). The positive expression of GAS and GRP in gastric cancer was correlated with lymph node metastasis (P< 0.05).</p><p><b>CONCLUSION</b>Tissue chip technique is a feasible,rapid,economic and accurate approach for screening clinical tissue specimens on a large scale.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Stomach Neoplasms
/
Gastrins
/
Immunohistochemistry
/
Gastrin-Releasing Peptide
/
Protein Array Analysis
/
Metabolism
/
Methods
/
Neoplasm Invasiveness
/
Neoplasm Staging
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS