Advances of research on the mechanism of Down syndrome birth at advanced maternal age / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 863-866, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-345345
ABSTRACT
Down syndrome is caused by partial or complete triplication of genes located on chromosome 21. Its incidence increases dramatically with the age of women. Hypotheses proposed for this have included abnormal homologous recombination, defective spindle assembly, biological aging, reduction of cohesion complexes, endocrine disorders, oocyte selection model, and single nucleotide polymorphisms of genes that maintain chromosome stability, etc. A literature review is provided here.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oocytes
/
Chromosomes, Human, Pair 21
/
Aging
/
Maternal Age
/
Down Syndrome
/
Polymorphism, Single Nucleotide
/
Genetics
/
Metabolism
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2016
Type:
Article
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