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Evaluation of antibacterial activity of amoxycillin sodium and clavulanate potassium and the pharmacoeconomics in the therapy of acute respiratory infection / 中华儿科杂志
Chinese Journal of Pediatrics ; (12): 352-356, 2003.
Article in Chinese | WPRIM | ID: wpr-345493
ABSTRACT
<p><b>OBJECTIVE</b>To explore the antibacterial activity of amoxycillin sodium and clavulanate potassium (trade name Anqi) in vitro and the pharmacoeconomics in the therapy of acute respiratory infection.</p><p><b>METHODS</b>Minimal inhibition concentration (MIC), minimal bactericidal concentration (MBC) and bactericidal curve of amoxycillin sodium and clavulanate potassium against common pathogens were determined and compared with some other same kind of antibiotics without beta-Lactamase inhibitor. Eighty cases diagnosed as respiratory infection were randomly divided into 4 groups group 1 was treated with i.v. Anqi; group 2 was treated with i.v. Anqi and oral consecutive strategy; group 3 was treated with iv ampicillin and sulbactam; group 4 was treated with i.v. cefuroxime. The clinical therapeutic effects were observed and cost-effectiveness analyzed.</p><p><b>RESULTS</b>In terms of MIC, MBC and bactericidal curve of 135 bacterial strains, Anqi was superior to the other same-kind antibiotics without beta-lactamase inhibitor, this effect was especially obvious on Klebsiella pneumoniae and Escherichia coli which can produce extended spectrum beta-lactamases (ESBLs). The cost-effectiveness of the consecutive therapy group was the best.</p><p><b>CONCLUSION</b>Anqi has a wide antimicrobial spectrum and strong effect on the bacteria producing ESBLs, the consecutive therapy strategy should be clinically recommended.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Respirovirus Infections / Pharmacology / Bacteria / Microbial Sensitivity Tests / Treatment Outcome / Clavulanic Acid / Therapeutic Uses / Dose-Response Relationship, Drug / Drug Therapy / Drug Therapy, Combination Type of study: Health economic evaluation Limits: Child / Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Pediatrics Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Respirovirus Infections / Pharmacology / Bacteria / Microbial Sensitivity Tests / Treatment Outcome / Clavulanic Acid / Therapeutic Uses / Dose-Response Relationship, Drug / Drug Therapy / Drug Therapy, Combination Type of study: Health economic evaluation Limits: Child / Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Pediatrics Year: 2003 Type: Article