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Determination and clinical significance of serum surfactant proteins A and D in children with bronchiolitis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 987-989, 2013.
Article in Chinese | WPRIM | ID: wpr-345664
ABSTRACT
<p><b>OBJECTIVE</b>To study the variation and clinical significance of serum levels of surfactant proteins A (SP-A) and D (SP-D) among children with different degrees of bronchiolitis.</p><p><b>METHODS</b>Seventy children with bronchiolitis were divided into acute (n=42) and recovery phase groups (n=28). According to the severity of symptoms, the acute phase group was further divided into severe (n=12) and mild subgroups (n=30). Another 26 children who were hospitalized in the same period due to non-infectious diseases and had not undergone surgery were used as the control group. Competitive enzyme-linked immunosorbent assay was performed to measure serum levels of SP-A and SP-D in each group.</p><p><b>RESULTS</b>The acute phase group had significantly higher serum levels of SP-A and SP-D compared with the recovery phase (P<0.01) and control groups (P<0.01). Compared with the control group, the recovery phase group had elevated levels of SP-A and SP-D (P<0.01). Within the acute phase group, serum levels of SP-A and SP-D in the severe subgroup were significantly higher than in the mild subgroup (P<0.01).</p><p><b>CONCLUSIONS</b>Serum levels of SP-A and SP-D are significantly elevated in children with acute bronchiolitis, and severe cases have higher serum levels of SP-A and SP-D than mild cases. Even after the relief of clinical symptoms, serum levels of SP-A and SP-D remain high. These findings suggest that serum levels of SP-A and SP-D might be useful biomarkers for evaluating the severity of bronchiolitis among children.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Severity of Illness Index / Bronchiolitis / Biomarkers / Acute Disease / Pulmonary Surfactant-Associated Protein A / Pulmonary Surfactant-Associated Protein D Limits: Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Severity of Illness Index / Bronchiolitis / Biomarkers / Acute Disease / Pulmonary Surfactant-Associated Protein A / Pulmonary Surfactant-Associated Protein D Limits: Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2013 Type: Article