Prevalence of Antibody to Toxic Shock Syndrome Toxin-1 in Burn Patients
Annals of Laboratory Medicine
;
: 89-93, 2015.
Article
in English
| WPRIM
| ID: wpr-34570
ABSTRACT
BACKGROUND:
Burn wounds lack normal barriers that protect against pathogenic bacteria, and burn patients are easily colonized and infected by Staphylococcus aureus. Toxic shock syndrome (TSS) is a rare but fatal disease caused by S. aureus. A lack of detectable antibodies to TSS toxin-1 (TSST-1) in serum indicates susceptibility to TSS.METHODS:
A total of 207 patients (169 men and 38 women; median age, 42.5 yr) admitted to a burn center in Korea were enrolled in this study. The serum antibody titer to TSST-1 was measured by sandwich ELISA. S. aureus isolates from the patients' nasal swab culture were tested for TSST-1 toxin production by PCR-based detection of the TSST-1 toxin gene.RESULTS:
One hundred seventy-four (84.1%) patients showed positive results for antibody against TSST-1. All patients aged > or =61 yr (n=28) and <26 months (n=7) were positive for the anti-TSST-1 antibody. S. aureus was isolated from 70 patients (33.8%), and 58.6% of the isolates were methicillin resistant. Seventeen patients were colonized with TSST-1-producing S. aureus. The antibody positivity in these 17 carriers was 88.2%, and the positivity in the non-carriers was 83.7%.CONCLUSIONS:
Most burn patients had antibody to TSST-1, and nasal colonization with TSST-1-producing S. aureus was associated with positive titers of anti-TSST-1 antibody. Additionally, patients with negative titers of anti-TSST-1 antibody might be susceptible to TSS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Staphylococcal Infections
/
Staphylococcus aureus
/
Bacterial Toxins
/
Burns
/
Enzyme-Linked Immunosorbent Assay
/
Polymerase Chain Reaction
/
Prevalence
/
Superantigens
/
Enterotoxins
/
Antibodies, Bacterial
Type of study:
Prevalence study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2015
Type:
Article
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