Relationship between the expression of E-cadherin and MVD and its significance in lung cancer / 中国肺癌杂志

ABSTRACT

<p><b>BACKGROUND</b>To study the relationship between the expression of E-cadherin and MVD in lung cancer and its significance.</p><p><b>METHODS</b>The expressions of E-cadherin and factor VIII were detected in 104 lung cancer tissues by immunohistochemical method, and MVD was calculated by image analysis system.</p><p><b>RESULTS</b>The expression of E-cadherin was significantly related to the differentiation of lung cancer (P < 0.05). A negative correlation was observed between E-cadherin expression and MVD in lung cancer tissues (P= 0.047).</p><p><b>CONCLUSIONS</b>Downexpression of E-cadherin and increase of MVD may play an important role in the invasion and metastasis of lung cancer, and may also be used as a useful marker for tumor prognosis.</p>