Study on a novel vascular stent material (titanium oxide, Ti-O) coated with albumin and heparin: is it hemocompatible with fibrinogen / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1097-1101, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-346002
ABSTRACT
The functional hemocompatibility between fibrinogen (FIG) and a novel vascular stent material (Ti-O film fixed with albumin and heparin) was investigated as follows (1) Preparing the new biologic material (Ti-O) film; (2) Coating albumin and heparin on the Ti-O film; (3) Testing platelets (PL) adsorption; (4) Determining FIG adhesion number by use of enzyme linked immunoassay (ELISA); (5) Implanting the films from the test group of Ti-O film and from the comparison group of stainless steel (SS) film into the left and right femoral arteries respectively in 4 dogs. It was proved that albumin and heparin were fixed on Ti-O film. After 6 months, the femoral arteries of the dogs were resected. In the test group of Ti-O film coated with albumin and heparin, few PL adhered to the coat, their form did not change, and no thrombus was found by scanning electron microscopy; the result was better than that of plain Ti-O film, and was much better than that of SS film. Ti-O maintained normal transformation condition of FIG, and no C terminal of gamma chain in FIG was revealed. As it is known whether the hemocompatibility of a biomaterial is good depends upon its adsorption of FIG, and Ti-O has excellent reaction on albumin and heparin by chemical processes. In this study, the Ti-O film coated with albumin and heparin further reduced the absorption of FIG and PL when compared against the plain Ti-O film. So the Ti-O film coated with albumin and heparin has the insistent and permanent anticoagulant character.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Prosthesis Design
/
Surface Properties
/
Titanium
/
Materials Testing
/
Fibrinogen
/
Heparin
/
Stents
/
Chemistry
/
Coated Materials, Biocompatible
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2007
Type:
Article
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