Pharmacokinetics of photosensitizer m-THPC in rat models of liver cancer via orthotropic implantation using Walker-256 / 中华外科杂志
Chinese Journal of Surgery
;
(12): 341-345, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-346308
ABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetics, distribution and excretion of m-THPC in rat models of liver cancer via orthotropic implantation using Walker-256.</p><p><b>METHODS</b>After an intravenous injection of m-THPC with 0.3 mg/kg, the concentrations of m-THPC in biological specimens were determined by a fluorescence method. The data obtained were processed with PK-GRAPH pharmacokinetic procedure.</p><p><b>RESULTS</b>The disposition of m-THPC in rat models of liver cancer Walker-256 was conformed to a two compartment model with T(1/2)α = 1.18 h, T(1/2)β = 22.57 h at the dose of 0.3 mg/kg.m-THPC was shown to be widely distributed to the various tissues. There was a highest drug accumulation in liver and liver cancer, and lowest in skin and muscle. Ratio of m-THPC concentration in the Walker-256 tumor compared to normal tissue reach the peak 24 h after m-THPC administration.</p><p><b>CONCLUSIONS</b>m-THPC is distributed widely and eliminated at a rapid rate in Walker-256 rats. Twenty four hours after m-THPC administration may be the best time for photodynamic therapy of liver cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organophosphorus Compounds
/
Pharmacokinetics
/
Tissue Distribution
/
Rats, Wistar
/
Photosensitizing Agents
/
Liver Neoplasms, Experimental
/
Metabolism
/
Neoplasm Transplantation
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2011
Type:
Article
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