Pharmacokinetics behavior of raltitrexed in rats after single injected with astragali radix / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1823-1826, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-346491
ABSTRACT
To study pharmacokinetics behavior of Raltitrexed (RTX) after single injected with Radix Astragali (RA); twelve rats were divided into two groups RTX (administrated iv. of raltitrexed); RTX with RA (administrated iv. of raltitrexed after single iv. dose of 3. 15 g x kg(-1)), rat plasma was collected and processed before HPLC assays; The established HPLC method was rapid, specific and precise. Between RTX and RTX with RA groups, half-life (t1/2), AUC(0-t) and CL showed no statistically significant differences; RA co-administration did not affect the pharmacokinetics of raltitrexed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quinazolines
/
Thiophenes
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Rats, Sprague-Dawley
/
Astragalus Plant
/
Drug Interactions
/
Antineoplastic Agents
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article
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