Genetic polymorphism of tumor necrosis factor-alpha in patients with chronic benzene poisoning / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 195-198, 2005.
Article
in Zh
| WPRIM
| ID: wpr-346533
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between genetic polymorphism of tumor necrosis factor-alpha (TNF-alpha, sites at -238 nt and -308 nt) and susceptibility to chronic benzene poisoning.</p><p><b>METHOD</b>The polymorphism of TNF-alpha gene were detected by nested polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique from 50 benzene poisoning patients and 60 control individuals exposed to benzene.</p><p><b>RESULTS</b>The frequency of the TNF-alpha-238G/G, A/G and A/A in controls (95%, 5% and 0%, respectively), were not significantly different from those in patients (92%, 6% and 2%, respectively, P > 0.05). The frequency of the TNF-alpha-308G/G, A/G and A/A in patients were 76%, 24% and 0% respectively, and that in control individuals were 93%, 7% and 0% respectively. Chi(2) test showed that frequency of TNF-alpha-308A/G in patients was significantly higher than that in controls (chi(2) = 6.22, P = 0.013). Logistic analysis showed that TNF-alpha-308A/G was the independent risk factor of benzene poisoning (OR = 5.3, P < 0.05).</p><p><b>CONCLUSION</b>Individuals with TNF-alpha-308A/G gene polymorphism are susceptible to benzene poisoning.</p>
Full text:
1
Index:
WPRIM
Main subject:
Poisoning
/
Polymorphism, Genetic
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Benzene
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Polymorphism, Restriction Fragment Length
/
Polymerase Chain Reaction
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Chronic Disease
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Tumor Necrosis Factor-alpha
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Genetic Predisposition to Disease
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Genetics
/
Genotype
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2005
Type:
Article