Expression of survivin, Bcl-2 and p53 during 4-nitro-quinoline 1-oxide-induced rat tongue carcinogenesis / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 168-171, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-346710
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of survivin during oral carcinogenesis and its relationship with the expression of Bcl-2 and p53.</p><p><b>METHODS</b>Two-step immunohistochemical method was employed to detect the expression of survivin, Bcl-2 and p53 in 60 rat tongue carcinogenesis specimens induced by 4-nitro-quinoline 1-oxide (4NQO).</p><p><b>RESULTS</b>Survivin was present in 1/36 cases of normal mucosa, 6/11 cases of oral epithelial dysplasia and 10/11 cases of oral carcinoma. There were significant difference in the expression of survivin among normal mucosa, oral epithelial dysplasia and carcinoma (P < 0.001). While in the 17 cases of positive expression of survivin, Bcl-2 was present in 12 cases and p53 was present in 8 cases. The expression of survivin in oral epithelial dysplasia and carcinoma were significantly higher than that in normal oral mucosa (P < 0.01). The expression of survivin was positively correlated to the expression of Bcl-2 and p53 in rat tongue (P < 0.01).</p><p><b>CONCLUSIONS</b>The expression of survivin may play an important role in oral carcinogenesis. Survivin, Bcl-2 and p53 may be synergetic in the carcinogenesis of oral cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Tongue Neoplasms
/
Cell Transformation, Neoplastic
/
Tumor Suppressor Protein p53
/
Apoptosis
/
Proto-Oncogene Proteins c-bcl-2
/
Genes, bcl-2
/
Metabolism
/
Microtubule-Associated Proteins
/
Mouth Mucosa
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Stomatology
Year:
2009
Type:
Article
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